Praet, S
(5) Adverse Effects and Contraindications: The most notable adverse effect is increased blood pressure
They add that as immunotherapies are being more commonly utilized as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles heel of immunotherapy. In their Cancer Immunology Research paper, Bluestone and colleagues briefly discuss immunotherapeutic strategies that can potentially prevent irAEs, such as targeting intratumoral T cells directly, using bispecific antibodies to enhance localized targeting of tumor, and using engineered cell therapies to fine-tune immune cell responses
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NF-kB is activated by canonical and non-canonical signalling pathways which has different signalling compounds and its biological functions
90,91 There are a few well-documented drug interactions, including cholestyramine that impairs the absorption of Leflunomide, rifampin side effects caused by raising Leflunomide levels in the blood, and Leflunomide rarely increasing the anticoagulant effect of warfarin
